Wednesday, 14 December 2011

Glucosamine Pharma Nord




Glucosamine Pharma Nord may be available in the countries listed below.


Ingredient matches for Glucosamine Pharma Nord



Glucosamine

Glucosamine is reported as an ingredient of Glucosamine Pharma Nord in the following countries:


  • Belgium

  • Ireland

Glucosamine sulfate (a derivative of Glucosamine) is reported as an ingredient of Glucosamine Pharma Nord in the following countries:


  • Estonia

  • Latvia

  • Lithuania

  • Netherlands

International Drug Name Search

Tuesday, 13 December 2011

Isosorbidemononitraat




Isosorbidemononitraat may be available in the countries listed below.


Ingredient matches for Isosorbidemononitraat



Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Isosorbidemononitraat in the following countries:


  • Netherlands

International Drug Name Search

Tuesday, 6 December 2011

Normolaxil




Normolaxil may be available in the countries listed below.


Ingredient matches for Normolaxil



Lactitol

Lactitol is reported as an ingredient of Normolaxil in the following countries:


  • Luxembourg

Lactitol monohydrate (a derivative of Lactitol) is reported as an ingredient of Normolaxil in the following countries:


  • Belgium

International Drug Name Search

Monday, 5 December 2011

Apo-Metformin




Apo-Metformin may be available in the countries listed below.


Ingredient matches for Apo-Metformin



Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Apo-Metformin in the following countries:


  • Canada

  • Guyana

  • Vietnam

International Drug Name Search

Friday, 25 November 2011

Tolbutamide Actavis




Tolbutamide Actavis may be available in the countries listed below.


Ingredient matches for Tolbutamide Actavis



Tolbutamide

Tolbutamide is reported as an ingredient of Tolbutamide Actavis in the following countries:


  • Netherlands

International Drug Name Search

Monday, 21 November 2011

Ticlopidine Arrow




Ticlopidine Arrow may be available in the countries listed below.


Ingredient matches for Ticlopidine Arrow



Ticlopidine

Ticlopidine hydrochloride (a derivative of Ticlopidine) is reported as an ingredient of Ticlopidine Arrow in the following countries:


  • France

International Drug Name Search

Monday, 14 November 2011

Clomazol




Clomazol may be available in the countries listed below.


Ingredient matches for Clomazol



Clotrimazole

Clotrimazole is reported as an ingredient of Clomazol in the following countries:


  • Ecuador

International Drug Name Search

Saturday, 12 November 2011

Zutex




Zutex may be available in the countries listed below.


Ingredient matches for Zutex



Ceftriaxone

Ceftriaxone is reported as an ingredient of Zutex in the following countries:


  • India

International Drug Name Search

Friday, 11 November 2011

Fenogal Lidose




Fenogal Lidose may be available in the countries listed below.


Ingredient matches for Fenogal Lidose



Fenofibrate

Fenofibrate is reported as an ingredient of Fenogal Lidose in the following countries:


  • Singapore

International Drug Name Search

Monday, 7 November 2011

Sertralina Vir




Sertralina Vir may be available in the countries listed below.


Ingredient matches for Sertralina Vir



Sertraline

Sertraline hydrochloride (a derivative of Sertraline) is reported as an ingredient of Sertralina Vir in the following countries:


  • Spain

International Drug Name Search

Friday, 4 November 2011

Virorrever




Virorrever may be available in the countries listed below.


Ingredient matches for Virorrever



Efavirenz

Efavirenz is reported as an ingredient of Virorrever in the following countries:


  • Argentina

International Drug Name Search

Monday, 24 October 2011

Chloramphecort




Chloramphecort may be available in the countries listed below.


Ingredient matches for Chloramphecort



Chloramphenicol

Chloramphenicol is reported as an ingredient of Chloramphecort in the following countries:


  • Indonesia

Hydrocortisone

Hydrocortisone is reported as an ingredient of Chloramphecort in the following countries:


  • Indonesia

International Drug Name Search

Thursday, 20 October 2011

Manicol




Manicol may be available in the countries listed below.


Ingredient matches for Manicol



Mannitol

Mannitol is reported as an ingredient of Manicol in the following countries:


  • France

International Drug Name Search

Friday, 14 October 2011

Declovir




Declovir may be available in the countries listed below.


Ingredient matches for Declovir



Acyclovir

Aciclovir is reported as an ingredient of Declovir in the following countries:


  • Ethiopia

  • Myanmar

International Drug Name Search

Tuesday, 11 October 2011

Tetrilin




Tetrilin may be available in the countries listed below.


Ingredient matches for Tetrilin



Tetryzoline

Tetryzoline hydrochloride (a derivative of Tetryzoline) is reported as an ingredient of Tetrilin in the following countries:


  • Germany

International Drug Name Search

Thursday, 6 October 2011

Ocupred




Ocupred may be available in the countries listed below.


Ingredient matches for Ocupred



Prednisolone

Prednisolone 21-acetate (a derivative of Prednisolone) is reported as an ingredient of Ocupred in the following countries:


  • Venezuela

International Drug Name Search

Monday, 3 October 2011

Rinoflumil




Rinoflumil may be available in the countries listed below.


Ingredient matches for Rinoflumil



Acetylcysteine

Acetylcysteine is reported as an ingredient of Rinoflumil in the following countries:


  • Spain

Tuaminoheptane

Tuaminoheptane sulfate (a derivative of Tuaminoheptane) is reported as an ingredient of Rinoflumil in the following countries:


  • Spain

International Drug Name Search

Wednesday, 28 September 2011

Roxihexal




Roxihexal may be available in the countries listed below.


Ingredient matches for Roxihexal



Roxithromycin

Roxithromycin is reported as an ingredient of Roxihexal in the following countries:


  • Bulgaria

  • Georgia

  • Germany

  • Russian Federation

International Drug Name Search

Friday, 23 September 2011

Voltarenactigo




Voltarenactigo may be available in the countries listed below.


Ingredient matches for Voltarenactigo



Diclofenac

Diclofenac diethylamine (a derivative of Diclofenac) is reported as an ingredient of Voltarenactigo in the following countries:


  • France

International Drug Name Search

Thursday, 22 September 2011

Somatropin




In the US, Somatropin (somatropin systemic) is a member of the drug class growth hormones and is used to treat Adult Human Growth Hormone Deficiency, AIDS Related Wasting, Burns - Nitrogen Retention, Cachexia, Growth Retardation - Chronic Renal Failure, Hypopituitarism, Idiopathic Short Stature, Noonan's Syndrome, Pediatric Growth Hormone Deficiency, Short Bowel Syndrome, Short Stature for Age and Turner's Syndrome.

US matches:

  • Somatropin (rDNA origin - Nonrefrigerated)

  • Somatropin (rDNA origin - Refrigerated)

  • Somatropin (rDNA origin - Refrigerated) Cartridge

  • Somatropin (rDNA origin - Refrigerated) Vial

  • Somatropin (rDNA origin - Refrigerated) Vials

  • Somatropin

  • Somatropin, e-coli derived Subcutaneous, Injection

  • Somatropin, mammalian derived Subcutaneous, Injection

Ingredient matches for Somatropin



Somatropine

Somatropin (BAN, JAN, USAN) is also known as Somatropine (Rec.INN)

International Drug Name Search

Glossary

BANBritish Approved Name
JANJapanese Accepted Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Tuesday, 20 September 2011

Lupron Depot


See also: Generic Lupron Depot-PED


Lupron Depot is a brand name of leuprolide, approved by the FDA in the following formulation(s):


LUPRON DEPOT (leuprolide acetate - injectable; injection)



  • Manufacturer: ABBOTT ENDOCRINE

    Approval date: December 22, 1995

    Strength(s): 22.5MG/VIAL [RLD]


  • Manufacturer: ABBOTT ENDOCRINE

    Approval date: May 30, 1997

    Strength(s): 30MG/VIAL [RLD]


  • Manufacturer: ABBOTT ENDOCRINE

    Approval date: June 17, 2011

    Strength(s): 45MG/VIAL


  • Manufacturer: ABBOTT LABS

    Approval date: January 26, 1989

    Strength(s): 7.5MG/VIAL [RLD]


  • Manufacturer: ABBOTT LABS

    Approval date: October 22, 1990

    Strength(s): 3.75MG/VIAL [RLD]


  • Manufacturer: ABBOTT LABS

    Approval date: March 7, 1997

    Strength(s): 11.25MG/VIAL [RLD]

Has a generic version of Lupron Depot been approved?


No. There is currently no therapeutically equivalent version of Lupron Depot available.


Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Lupron Depot. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.




Related Patents


Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.




  • Prolonged release microcapsules
    Patent 5,480,656
    Issued: January 2, 1996
    Inventor(s): Okada; Hiroaki & Inoue; Yayoi & Ogawa; Yasuaki
    Assignee(s): Takeda Chemical Industries, Ltd.
    This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, wherein the composition ratio of lactic acid/glycolic acid in the copolymer or homopolymer is 80/10 to 100/0, and then subjecting said water-in oil emulsion to microencapsulation.
    Patent expiration dates:

    • January 2, 2013




  • Method of producing sustained-release microcapsules
    Patent 5,575,987
    Issued: November 19, 1996
    Inventor(s): Kamei; Shigeru & Yamada; Minoru & Ogawa; Yasuaki
    Assignee(s): Takeda Chemical Industries, Ltd.
    A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.
    Patent expiration dates:

    • September 2, 2013




  • Method for producing microcapsule
    Patent 5,631,020
    Issued: May 20, 1997
    Inventor(s): Okada; Hiroaki & Ogawa; Yasuaki & Yashiki; Takatsuka
    Assignee(s): Takeda Chemical Industries, Ltd.
    A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.
    Patent expiration dates:

    • May 20, 2014




  • Method for producing microcapsule
    Patent 5,631,021
    Issued: May 20, 1997
    Inventor(s): Okada; Hiroaki & Ogawa; Yasuaki & Yashiki; Takatsuka
    Assignee(s): Takeda Chemical Industries, Ltd.
    A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.
    Patent expiration dates:

    • May 20, 2014




  • Prolonged release microcapsules
    Patent 5,643,607
    Issued: July 1, 1997
    Inventor(s): Okada; Hiroaki & Inoue; Yayoi & Ogawa; Yasuaki
    Assignee(s): Takeda Chemical Industries, Ltd.
    This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, wherein the composition ratio of lactic acid/glycolic acid in the copolymer or homopolymer is 80/10 to 100/0, and then subjecting said water-in oil emulsion to microencapsulation.
    Patent expiration dates:

    • January 2, 2013




  • Method of producing sustained-release microcapsules
    Patent 5,716,640
    Issued: February 10, 1998
    Inventor(s): Kamei; Shigeru & Yamada; Minoru & Ogawa; Yasuaki
    Assignee(s): Takeda Chemical Industries, Ltd.
    A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.
    Patent expiration dates:

    • September 2, 2013




  • Sustained release microspheres and preparation thereof
    Patent 6,036,976
    Issued: March 14, 2000
    Inventor(s): Takechi; Nobuyuki & Ohtani; Seiji & Nagai; Akihiro
    Assignee(s): Takeda Chemical Industries, Ltd.
    Disclosed is a method of producing microspheres which comprises subjecting a w/o/w emulsion or o/w emulsion to an in-water drying method under the following conditions: 1) the amount of microspheres per m.sup.3 of an external aqueous phase is about 0.1 to about 500 kg, 2) the square root of the area (unit: m.sup.2) of the liquid surface in contact with the gas phase is about 0.2 to about 4.5 per the cube root of the volume (unit: m.sup.3) of an external aqueous phase, 3) the w/o/w emulsion or o/w emulsion is replaced at the replacement frequency of about 0.01 to about 10 times/minutes, 4) a gas is blown to the w/o/w emulsion or o/w emulsion at the gas transfer rate near the liquid surface of about 0.1 to about 300 m/second, and 5) the gas is replaced at the replacement frequency of not less than about 0.5 times/minutes; and the method of the present invention increases the rate of solvent removal from microspheres in in-water drying, reduces the amount of solvent in microspheres in a short time.
    Patent expiration dates:

    • December 13, 2016


    • December 13, 2016
      ✓ 
      Drug product




  • Controlled release composition and method of producing the same
    Patent 7,429,559
    Issued: September 30, 2008
    Inventor(s): Yamamoto; Kazumichi & Yamada; Akiko & Hata; Yoshio
    Assignee(s): Takeda Pharmaceutical Company Limited
    A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
    Patent expiration dates:

    • December 13, 2016
      ✓ 
      Drug product



Related Exclusivities

Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.

  • Exclusivity expiration dates:
    • June 17, 2014 - 45MG FOR 6 MONTH ADMINISTRATION

    • June 17, 2014 - NEW STRENGTH

See also...

  • Lupron Depot Consumer Information (Wolters Kluwer)
  • Lupron Depot Depot Suspension Consumer Information (Wolters Kluwer)
  • Lupron Depot Suspension Consumer Information (Wolters Kluwer)
  • Lupron Depot Consumer Information (Cerner Multum)
  • Lupron Depot Advanced Consumer Information (Micromedex)
  • Leuprolide Consumer Information (Wolters Kluwer)
  • Leuprolide Depot Suspension Consumer Information (Wolters Kluwer)
  • Leuprolide Implant Consumer Information (Wolters Kluwer)
  • Leuprolide Kit Consumer Information (Wolters Kluwer)
  • Leuprolide Suspension Consumer Information (Wolters Kluwer)
  • Leuprolide Consumer Information (Cerner Multum)
  • Leuprolide Intramuscular, Subcutaneous, Intradermal, Injection Advanced Consumer Information (Micromedex)
  • Leuprolide Acetate AHFS DI Monographs (ASHP)

Xylocain mit Adrenalin




Xylocain mit Adrenalin may be available in the countries listed below.


Ingredient matches for Xylocain mit Adrenalin



Epinephrine

Epinephrine bitartrate (a derivative of Epinephrine) is reported as an ingredient of Xylocain mit Adrenalin in the following countries:


  • Germany

Lidocaine

Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Xylocain mit Adrenalin in the following countries:


  • Germany

Lidocaine hydrochloride monohydrate (a derivative of Lidocaine) is reported as an ingredient of Xylocain mit Adrenalin in the following countries:


  • Germany

International Drug Name Search

Thursday, 15 September 2011

Flumil




Flumil may be available in the countries listed below.


Ingredient matches for Flumil



Acetylcysteine

Acetylcysteine is reported as an ingredient of Flumil in the following countries:


  • Spain

Fluconazole

Fluconazole is reported as an ingredient of Flumil in the following countries:


  • Peru

International Drug Name Search

Wednesday, 14 September 2011

Parofen




Parofen may be available in the countries listed below.


Ingredient matches for Parofen



Ibuprofen

Ibuprofen is reported as an ingredient of Parofen in the following countries:


  • Vietnam

International Drug Name Search

Monday, 12 September 2011

Mylepsinum




Mylepsinum may be available in the countries listed below.


Ingredient matches for Mylepsinum



Primidone

Primidone is reported as an ingredient of Mylepsinum in the following countries:


  • Germany

International Drug Name Search

Saturday, 27 August 2011

Simva Basics




Simva Basics may be available in the countries listed below.


Ingredient matches for Simva Basics



Simvastatin

Simvastatin is reported as an ingredient of Simva Basics in the following countries:


  • Germany

International Drug Name Search

Roxithromycin Stada




Roxithromycin Stada may be available in the countries listed below.


Ingredient matches for Roxithromycin Stada



Roxithromycin

Roxithromycin is reported as an ingredient of Roxithromycin Stada in the following countries:


  • Germany

International Drug Name Search

Wednesday, 24 August 2011

Nimesulida Ratiopharm




Nimesulida Ratiopharm may be available in the countries listed below.


Ingredient matches for Nimesulida Ratiopharm



Nimesulide

Nimesulide is reported as an ingredient of Nimesulida Ratiopharm in the following countries:


  • Portugal

International Drug Name Search

Saturday, 20 August 2011

Dolonet




Dolonet may be available in the countries listed below.


Ingredient matches for Dolonet



Ibuprofen

Ibuprofen is reported as an ingredient of Dolonet in the following countries:


  • Peru

International Drug Name Search

Monday, 8 August 2011

Ange




Ange may be available in the countries listed below.


Ingredient matches for Ange



Ethinylestradiol

Ethinylestradiol is reported as an ingredient of Ange in the following countries:


  • Japan

Levonorgestrel

Levonorgestrel is reported as an ingredient of Ange in the following countries:


  • Japan

International Drug Name Search

Sunday, 7 August 2011

Raloxifène




Raloxifène may be available in the countries listed below.


Ingredient matches for Raloxifène



Raloxifene

Raloxifène (DCF) is known as Raloxifene in the US.

International Drug Name Search

Glossary

DCFDénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Monday, 25 July 2011

Fabolergic




Fabolergic may be available in the countries listed below.


Ingredient matches for Fabolergic



Diphenhydramine

Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Fabolergic in the following countries:


  • Argentina

International Drug Name Search

Saturday, 23 July 2011

Euglitol




Euglitol may be available in the countries listed below.


Ingredient matches for Euglitol



Miglitol

Miglitol is reported as an ingredient of Euglitol in the following countries:


  • India

International Drug Name Search

Friday, 22 July 2011

Piperazyl




Piperazyl may be available in the countries listed below.


Ingredient matches for Piperazyl



Piperazine

Piperazine citrate (a derivative of Piperazine) is reported as an ingredient of Piperazyl in the following countries:


  • Ecuador

International Drug Name Search

Wednesday, 20 July 2011

GEL-PHAN




GEL-PHAN may be available in the countries listed below.


Ingredient matches for GEL-PHAN



Gelatin

Gelatin is reported as an ingredient of GEL-PHAN in the following countries:


  • France

International Drug Name Search

Friday, 15 July 2011

Ranitidine Etos




Ranitidine Etos may be available in the countries listed below.


Ingredient matches for Ranitidine Etos



Ranitidine

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Ranitidine Etos in the following countries:


  • Netherlands

International Drug Name Search

Thursday, 14 July 2011

Methanthelinium Bromide




Scheme

Prop.INN

CAS registry number (Chemical Abstracts Service)

0000053-46-3

Chemical Formula

C21-H26-Br-N-O3

Molecular Weight

420

Therapeutic Categories

Antispasmodic agent

Parasympatholytic agent

Gastric acid secretion inhibitor

Chemical Name

Ethanaminium, N,N-diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]-, bromide

Foreign Names

  • Methanthelinii bromidum (Latin)
  • Methanthelinium bromid (German)
  • Bromure de méthanthélinium (French)
  • Bromuro de metantelinio (Spanish)

Generic Names

  • Metantelinio bromuro (OS: DCIT)
  • Methanthelinium Bromide (OS: BAN)
  • Avagal (IS)
  • Dixamonum (IS)
  • MTB 51 (IS)
  • SC 2910 (IS)
  • Methantheline Bromide (PH: USP XXII)

Brand Name

  • Vagantin
    Riemser, Germany

International Drug Name Search

Glossary

BANBritish Approved Name
DCITDenominazione Comune Italiana
ISInofficial Synonym
OSOfficial Synonym
PHPharmacopoeia Name
Prop.INNProposed International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Thursday, 7 July 2011

Thioguanin-GSK




Thioguanin-GSK may be available in the countries listed below.


Ingredient matches for Thioguanin-GSK



Tioguanine

Tioguanine is reported as an ingredient of Thioguanin-GSK in the following countries:


  • Austria

  • Germany

International Drug Name Search

Monday, 4 July 2011

Ultrazole




Ultrazole may be available in the countries listed below.


Ingredient matches for Ultrazole



Lansoprazole

Lansoprazole is reported as an ingredient of Ultrazole in the following countries:


  • Oman

International Drug Name Search

Friday, 1 July 2011

Chian




Chian may be available in the countries listed below.


Ingredient matches for Chian



Glucosamine

Glucosamine sulfate (a derivative of Glucosamine) is reported as an ingredient of Chian in the following countries:


  • Taiwan

International Drug Name Search

Saturday, 25 June 2011

Miocor




Miocor may be available in the countries listed below.


Ingredient matches for Miocor



Amiodarone

Amiodarone hydrochloride (a derivative of Amiodarone) is reported as an ingredient of Miocor in the following countries:


  • Brazil

Levocarnitine

Levocarnitine is reported as an ingredient of Miocor in the following countries:


  • Italy

  • Romania

International Drug Name Search

Tuesday, 21 June 2011

clindamycine Fresenius




clindamycine Fresenius may be available in the countries listed below.


Ingredient matches for clindamycine Fresenius



Clindamycin

Clindamycin dihydrogen phosphate (a derivative of Clindamycin) is reported as an ingredient of clindamycine Fresenius in the following countries:


  • Netherlands

International Drug Name Search

Sunday, 12 June 2011

Sulfaquinoxaline Natrium




Sulfaquinoxaline Natrium may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Sulfaquinoxaline Natrium



Sulfaquinoxaline

Sulfaquinoxaline sodium salt (a derivative of Sulfaquinoxaline) is reported as an ingredient of Sulfaquinoxaline Natrium in the following countries:


  • Netherlands

International Drug Name Search

Saturday, 11 June 2011

Foot Rot Aerosol




Foot Rot Aerosol may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Foot Rot Aerosol



Cetrimide

Cetrimide is reported as an ingredient of Foot Rot Aerosol in the following countries:


  • United Kingdom

International Drug Name Search

Seeco Tylan




In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Seeco Tylan



Sulfadimidine

Sulfadimidine is reported as an ingredient of Seeco Tylan in the following countries:


  • United States

Tylosin

Tylosin phosphate (a derivative of Tylosin) is reported as an ingredient of Seeco Tylan in the following countries:


  • United States

International Drug Name Search

Wednesday, 8 June 2011

Dermal Necrosis, Treatment Medications


Drugs associated with Dermal Necrosis, Treatment

The following drugs and medications are in some way related to, or used in the treatment of Dermal Necrosis, Treatment. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Dermal Necrosis, Treatment





Drug List:

Saturday, 4 June 2011

Atropin EDO




Atropin EDO may be available in the countries listed below.


Ingredient matches for Atropin EDO



Atropine

Atropine sulfate (a derivative of Atropine) is reported as an ingredient of Atropin EDO in the following countries:


  • Germany

International Drug Name Search

Thursday, 2 June 2011

Palitenox




Palitenox may be available in the countries listed below.


Ingredient matches for Palitenox



Tenoxicam

Tenoxicam is reported as an ingredient of Palitenox in the following countries:


  • Greece

  • Oman

International Drug Name Search

Friday, 27 May 2011

Amoxivet




Amoxivet may be available in the countries listed below.


Ingredient matches for Amoxivet



Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxivet in the following countries:


  • Mexico

International Drug Name Search

Thursday, 19 May 2011

Indapamide Teva




Indapamide Teva may be available in the countries listed below.


Ingredient matches for Indapamide Teva



Indapamide

Indapamide is reported as an ingredient of Indapamide Teva in the following countries:


  • France

International Drug Name Search

Sunday, 8 May 2011

Alkosalen




Alkosalen may be available in the countries listed below.


Ingredient matches for Alkosalen



Flumetasone

Flumetasone 21-pivalate (a derivative of Flumetasone) is reported as an ingredient of Alkosalen in the following countries:


  • France

Salicylic Acid

Salicylic Acid is reported as an ingredient of Alkosalen in the following countries:


  • France

International Drug Name Search

Sunday, 1 May 2011

Magnerot




Magnerot may be available in the countries listed below.


Ingredient matches for Magnerot



Magnesium Gluconate

Magnesium Gluconate dihydrate (a derivative of Magnesium Gluconate) is reported as an ingredient of Magnerot in the following countries:


  • Germany

Magnesium Hydrogen Aspartate

Magnesium Hydrogen Aspartate dihydrate (a derivative of Magnesium Hydrogen Aspartate) is reported as an ingredient of Magnerot in the following countries:


  • Germany

Magnesium Hydrogen Aspartate tetrahydrate (a derivative of Magnesium Hydrogen Aspartate) is reported as an ingredient of Magnerot in the following countries:


  • Germany

Magnesium Orotate

Magnesium Orotate is reported as an ingredient of Magnerot in the following countries:


  • Czech Republic

Magnesium Orotate dihydrate (a derivative of Magnesium Orotate) is reported as an ingredient of Magnerot in the following countries:


  • Bulgaria

  • Georgia

  • Germany

  • Hungary

  • Latvia

  • Lithuania

  • Romania

  • Slovakia

International Drug Name Search

Wednesday, 27 April 2011

Lactulosa Farmindustria




Lactulosa Farmindustria may be available in the countries listed below.


Ingredient matches for Lactulosa Farmindustria



Lactulose

Lactulose is reported as an ingredient of Lactulosa Farmindustria in the following countries:


  • Peru

International Drug Name Search

Thursday, 21 April 2011

Trimetazide




Trimetazide may be available in the countries listed below.


Ingredient matches for Trimetazide



Trimetazidine

Trimetazidine is reported as an ingredient of Trimetazide in the following countries:


  • Russian Federation

International Drug Name Search

Monday, 18 April 2011

Enalapril-saar




Enalapril-saar may be available in the countries listed below.


Ingredient matches for Enalapril-saar



Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril-saar in the following countries:


  • Germany

International Drug Name Search

Friday, 15 April 2011

Beclometasona Merck




Beclometasona Merck may be available in the countries listed below.


Ingredient matches for Beclometasona Merck



Beclometasone

Beclometasone 17α,21-dipropionate (a derivative of Beclometasone) is reported as an ingredient of Beclometasona Merck in the following countries:


  • Colombia

International Drug Name Search

Monday, 11 April 2011

Montélukast




Montélukast may be available in the countries listed below.


Ingredient matches for Montélukast



Montelukast

Montélukast (DCF) is known as Montelukast in the US.

International Drug Name Search

Glossary

DCFDénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Friday, 8 April 2011

Trinitrosan




Trinitrosan may be available in the countries listed below.


Ingredient matches for Trinitrosan



Nitroglycerin

Nitroglycerin is reported as an ingredient of Trinitrosan in the following countries:


  • Croatia (Hrvatska)

  • Germany

  • Romania

International Drug Name Search

Portia




In the US, Portia (ethinyl estradiol/levonorgestrel systemic) is a member of the drug class contraceptives and is used to treat Abnormal Uterine Bleeding, Birth Control, Endometriosis, Gonadotropin Inhibition, Ovarian Cysts and Polycystic Ovary Syndrome.

US matches:

  • Portia

Ingredient matches for Portia



Ethinylestradiol

Ethinylestradiol is reported as an ingredient of Portia in the following countries:


  • Canada

  • United States

Levonorgestrel

Levonorgestrel is reported as an ingredient of Portia in the following countries:


  • Canada

  • United States

International Drug Name Search

Wednesday, 6 April 2011

Meptin Mini




Meptin Mini may be available in the countries listed below.


Ingredient matches for Meptin Mini



Procaterol

Procaterol hydrochloride (a derivative of Procaterol) is reported as an ingredient of Meptin Mini in the following countries:


  • Japan

International Drug Name Search

Flavuril




Flavuril may be available in the countries listed below.


Ingredient matches for Flavuril



Ipratropium

Ipratropium Bromide is reported as an ingredient of Flavuril in the following countries:


  • Peru

International Drug Name Search

Monday, 28 March 2011

Servitet




Servitet may be available in the countries listed below.


Ingredient matches for Servitet



Tetracycline

Tetracycline hydrochloride (a derivative of Tetracycline) is reported as an ingredient of Servitet in the following countries:


  • Bangladesh

International Drug Name Search

Saturday, 26 March 2011

Maprotilin-ratiopharm




Maprotilin-ratiopharm may be available in the countries listed below.


Ingredient matches for Maprotilin-ratiopharm



Maprotiline

Maprotiline hydrochloride (a derivative of Maprotiline) is reported as an ingredient of Maprotilin-ratiopharm in the following countries:


  • Germany

  • Taiwan

International Drug Name Search

Thursday, 24 March 2011

Papavérine Renaudin




Papavérine Renaudin may be available in the countries listed below.


Ingredient matches for Papavérine Renaudin



Papaverine

Papaverine hydrochloride (a derivative of Papaverine) is reported as an ingredient of Papavérine Renaudin in the following countries:


  • France

International Drug Name Search

Wednesday, 23 March 2011

Benoxygel




Benoxygel may be available in the countries listed below.


Ingredient matches for Benoxygel



Benzoyl Peroxide

Benzoyl Peroxide is reported as an ingredient of Benoxygel in the following countries:


  • Portugal

  • Spain

International Drug Name Search

Monday, 21 March 2011

Alendronat Ratiopharm




Alendronat Ratiopharm may be available in the countries listed below.


Ingredient matches for Alendronat Ratiopharm



Alendronic Acid

Alendronic Acid is reported as an ingredient of Alendronat Ratiopharm in the following countries:


  • Poland

Alendronic Acid sodium trihydrate (a derivative of Alendronic Acid) is reported as an ingredient of Alendronat Ratiopharm in the following countries:


  • Czech Republic

  • Denmark

  • Hungary

  • Slovakia

  • Sweden

International Drug Name Search

Saturday, 19 March 2011

iProfen




iProfen may be available in the countries listed below.


Ingredient matches for iProfen



Ibuprofen

Ibuprofen is reported as an ingredient of iProfen in the following countries:


  • Australia

International Drug Name Search

Ganvirel




Ganvirel may be available in the countries listed below.


Ingredient matches for Ganvirel



Lamivudine

Lamivudine is reported as an ingredient of Ganvirel in the following countries:


  • Argentina

International Drug Name Search

Tuesday, 8 March 2011

Gentreks




Gentreks may be available in the countries listed below.


Ingredient matches for Gentreks



Gentamicin

Gentamicin sulfate (a derivative of Gentamicin) is reported as an ingredient of Gentreks in the following countries:


  • Turkey

International Drug Name Search

Saturday, 5 March 2011

Oesclim


Generic Name: estrogen (Oral route, Parenteral route, Topical application route, Transdermal route)


Commonly used brand name(s)

In the U.S.


  • Alora

  • Cenestin

  • Climara

  • Divigel

  • Elestrin

  • Emcyt

  • Enjuvia

  • Esclim

  • Estinyl

  • EstroGel

  • Evamist

  • Femtrace

  • Gynodiol

  • Menest

  • Menostar

  • Ogen .625

  • Ogen 1.25

  • Ogen 2.5

  • Premarin

  • Vivelle

  • Vivelle-Dot

In Canada


  • Estraderm

  • Estradot Transdermal

  • Estradot Transdermal Therapeutic System

  • Estradot Transdermal Therapeutic System

  • Estrogel

  • Oesclim

  • Rhoxal-Estradiol Derm 50

  • Rhoxal-Estradiol Derm 75

  • Roxal-Estradiol Derm 100

  • Vivelle 100 Mcg

  • Vivelle 25 Mcg

Available Dosage Forms:


  • Tablet

  • Patch, Extended Release

  • Gel/Jelly

  • Spray

  • Emulsion

  • Tablet, Enteric Coated

  • Capsule

Uses For Oesclim


Estrogens are female hormones. They are produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years.


The ovaries begin to produce less estrogen after menopause (the change of life). This medicine is prescribed to make up for the lower amount of estrogen. Estrogens help relieve signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness.


Estrogens are prescribed for several reasons:


  • To provide additional hormone when the body does not produce enough of its own, such as during menopause or when female puberty (development of female sexual organs) does not occur on time. Other conditions include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or ovary problems (female hypogonadism or failure or removal of both ovaries).

  • To help prevent weakening of bones (osteoporosis) in women past menopause.

  • In the treatment of selected cases of breast cancer in men and women.

  • In the treatment of cancer of the prostate in men.

Estrogens may also be used for other conditions as determined by your doctor.


There is no medical evidence to support the belief that the use of estrogens will keep the patient feeling young, keep the skin soft, or delay the appearance of wrinkles. Nor has it been proven that the use of estrogens during menopause will relieve emotional and nervous symptoms, unless these symptoms are caused by other menopausal symptoms, such as hot flashes or hot flushes.


Estrogens are available only with your doctor's prescription.


Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, estrogen is used in certain patients with the following medical conditions:


  • Gender identity disorder, male-to-female transsexualism (person who is born as a man but adapts to a woman's lifestyle, sees himself as a woman, and feels like a woman instead of a man.

  • Osteoporosis caused by lack of estrogen before menopause.

  • Turner's syndrome (a genetic disorder).

Before Using Oesclim


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Use of this medicine before puberty is not recommended. Growth of bones can be stopped early. Girls and boys may develop growth of breasts. Girls may have vaginal changes, including vaginal bleeding.


This medicine may be used to start puberty in teenagers with some types of delayed puberty.


Geriatric


Elderly people are especially sensitive to the effects of estrogens. This may increase the chance of side effects during treatment, especially stroke, invasive breast cancer, and memory problems.


Pregnancy


Estrogens are not recommended for use during pregnancy or right after giving birth. Becoming pregnant or maintaining a pregnancy is not likely to occur around the time of menopause.


Certain estrogens have been shown to cause serious birth defects in humans and animals. Some daughters of women who took diethylstilbestrol (DES) during pregnancy have developed reproductive (genital) tract problems and, rarely, cancer of the vagina or cervix (opening to the uterus) when they reached childbearing age. Some sons of women who took DES during pregnancy have developed urinary-genital tract problems.


Breast Feeding


Use of this medicine is not recommended in nursing mothers. Estrogens pass into the breast milk and their possible effect on the baby is not known.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.


  • Rotavirus Vaccine, Live

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Adenovirus Vaccine Type 4, Live

  • Adenovirus Vaccine Type 7, Live

  • Bacillus of Calmette and Guerin Vaccine, Live

  • Boceprevir

  • Felbamate

  • Influenza Virus Vaccine, Live

  • Isotretinoin

  • Measles Virus Vaccine, Live

  • Mumps Virus Vaccine, Live

  • Paclitaxel

  • Paclitaxel Protein-Bound

  • Rotavirus Vaccine, Live

  • Rubella Virus Vaccine, Live

  • Smallpox Vaccine

  • St John's Wort

  • Theophylline

  • Tizanidine

  • Tranexamic Acid

  • Typhoid Vaccine

  • Varicella Virus Vaccine

  • Yellow Fever Vaccine

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:


For all patients


  • Asthma or

  • Calcium, too much or too little in blood or

  • Diabetes or

  • Epilepsy or seizures or

  • Heart problems or

  • Kidney problems or

  • Liver tumors, benign or

  • Lupus erythematosus, systemic or

  • Migraine headaches—Estrogens may worsen these conditions.

  • Blood clotting problems, or history of during previous estrogen therapy—Estrogens usually are not used until blood clotting problems stop; using estrogens is not a problem for most patients without a history of blood clotting problems due to estrogen use.

  • Breast cancer or

  • Bone cancer or

  • Cancer of the uterus or

  • Fibroid tumors of the uterus—Estrogens may interfere with the treatment of breast or bone cancer or worsen cancer of the uterus when these conditions are present.

  • Bulging eyes or

  • Double vision or

  • Migraine headache or

  • Vision changes, sudden onset including or

  • Vision loss, partial or complete—Estrogens may cause these problems. Tell your doctor if you have had any of these problems, especially while taking estrogen or oral contraceptives (“birth control pills”).

  • Changes in genital or vaginal bleeding of unknown causes—Use of estrogens may delay diagnosis or worsen condition. The reason for the bleeding should be determined before estrogens are used.

  • Endometriosis or

  • Gallbladder disease or gallstones, or history of or

  • High cholesterol or triglycerides, or history of or

  • Liver disease, or history of or

  • Pancreatitis (inflammation of pancreas) or

  • Porphyria—Estrogens may worsen these conditions. Although estrogens can improve blood cholesterol, they can worsen blood triglycerides for some people.

  • Hypothyroid (too little thyroid hormone)—Dose of thyroid medicine may need to be increased.

For males treated for breast or prostate cancer:


  • Blood clots or

  • Heart or circulation disease or

  • Stroke—Males with these medical problems may be more likely to have clotting problems while taking estrogens; the high doses of estrogens used to treat male breast or prostate cancer have been shown to increase the chances of heart attack, phlebitis (inflamed veins) caused by a blood clot, or blood clots in the lungs.

Proper Use of estrogen

This section provides information on the proper use of a number of products that contain estrogen. It may not be specific to Oesclim. Please read with care.


Take this medicine only as directed by your doctor. Do not take more of it and do not take or use it for a longer time than your doctor ordered. For patients taking any of the estrogens by mouth, try to take the medicine at the same time each day to reduce the possibility of side effects and to allow it to work better.


This medicine usually comes with patient information or directions. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.


For patients taking any of the estrogens by mouth or by injection:


  • Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food.

For patients using the transdermal (skin patch):


  • Wash and dry your hands thoroughly before and after handling the patch.

  • Apply the patch to a clean, dry, non-oily skin area of your lower abdomen, hips below the waist, or buttocks that has little or no hair and is free of cuts or irritation. The manufacturer of the 0.025-mg patch recommends that its patch be applied to the buttocks only. Furthermore, each new patch should be applied to a new site of application. For instance, if the old patch is taken off the left buttock, then apply the new patch to the right buttock.

  • Do not apply to the breasts. Also, do not apply to the waistline or anywhere else where tight clothes may rub the patch loose.

  • Press the patch firmly in place with the palm of your hand for about 10 seconds. Make sure there is good contact, especially around the edges.

  • If a patch becomes loose or falls off, you may reapply it or discard it and apply a new patch.

  • Each dose is best applied to a different area of skin on your lower abdomen, hips below the waist, or buttocks so that at least 1 week goes by before the same area is used again. This will help prevent skin irritation.

For patients using the topical emulsion (skin lotion):


  • Washing and drying hands thoroughly before each application.

  • Apply while you are sitting comfortably. Apply one pouch to each leg every morning.

  • Apply the entire contents of one pouch to clean, dry skin on the left thigh. Rub the emulsion into the entire thigh and calf for 3 minutes until thoroughly absorbed.

  • Apply entire contents of the second pouch to clean, dry skin on the right thigh. Rub the emulsion into the entire thigh and calf for 3 minutes until thoroughly absorbed.

  • Rub any remaining emulsion on both hands on the buttocks.

  • Washing and drying hands thoroughly after application.

  • To avoid transfer to other individuals, allow the application areas to dry completely before covering with clothing.

If you are using the Evamist® transdermal spray:


  • Spray the medicine on your skin on the inside of your forearm, between the elbow and the wrist.

  • Do not allow your child to touch the area of the arm where the medicine was sprayed. If you cannot avoid to come nearer with your child, wear clothes with long sleeves to cover the application site.

  • If your child comes in direct contact with the arm where the medicine was sprayed, wash your child's skin right away with soap and water.

  • Do not allow your pets to lick or touch the arm where the medicine was sprayed.

Dosing


The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For conjugated estrogens

  • For oral dosage form (tablets):
    • For treating breast cancer in women after menopause and in men:
      • Adults—10 milligrams (mg) three times a day for at least 3 months.


    • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
      • Adults—0.3 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may change the dose based on how your body responds to the medication.


    • To prevent loss of bone (osteoporosis):
      • Adults—0.3 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may change the dose based on how your body responds to the medication.


    • For treating ovary problems (female hypogonadism or for starting puberty):
      • Adults and teenagers—0.3 to 0.625 milligram (mg) a day. Your doctor may want you to take the medicine only on certain days of the month.


    • For treating ovary problems (failure or removal of both ovaries):
      • Adults—1.25 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating prostate cancer:
      • Adults—1.25 to 2.5 milligram (mg) three times a day.



  • For injection dosage form:
    • For controlling abnormal bleeding of the uterus:
      • Adults—25 milligrams (mg) injected into a muscle or vein. This may be repeated in six to twelve hours if needed.



  • For esterified estrogens

  • For oral dosage form (tablets):
    • For treating breast cancer in women after menopause and in men:
      • Adults—10 milligrams (mg) three times a day for at least three months.


    • For treating a genital skin condition (vulvar atrophy) or inflammation of the vagina (atrophic vaginitis), or to prevent loss of bone (osteoporosis):
      • Adults—0.3 to 1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating ovary problems (failure or removal of both ovaries):
      • Adults—1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating ovary problems (female hypogonadism):
      • Adults—2.5 to 7.5 mg a day. This dose may be divided up and taken in smaller doses. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating symptoms of menopause:
      • Adults—0.625 to 1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating prostate cancer:
      • Adults—1.25 to 2.5 mg three times a day.



  • For estradiol

  • For oral dosage form:
    • For treating breast cancer in women after menopause and in men:
      • Adults—10 milligrams (mg) three times a day for at least 3 months.


    • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), ovary problems (female hypogonadism or failure or removal of both ovaries), or symptoms of menopause:
      • Adults—At first, 1 to 2 milligrams (mg) one time per day for at least 3 months. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may also need to change the dose based on how your body responds to the medication.


    • For treating prostate cancer:
      • Adults—1 to 2 milligrams (mg) three times a day.


    • To prevent loss of bone (osteoporosis):
      • Adults—0.5 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.



  • For topical emulsion dosage form (skin lotion):
    • For treating symptoms of menopause:
      • Adults—1.74 grams (one pouch) applied to the skin of each leg (thigh and calf) once a day in the morning.



  • For transdermal dosage form (skin patches):
    • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), symptoms of menopause, ovary problems (female hypogonadism or failure or removal of both ovaries), or to prevent loss of bone (osteoporosis):
      • For the Climara patches

      • Adults—0.025 to 0.1 milligram (mg) (one patch) applied to the skin and worn for one week. Then, remove that patch and apply a new one. A new patch should be applied once a week for three weeks. During the fourth week, you may or may not wear a patch. Your health care professional will tell you what you should do for this fourth week. After the fourth week, you will repeat the cycle.

      • For the Alora, Estraderm, Estradot, Vivelle, or Vivelle-Dot patches

      • Adults—0.025 to 0.1 mg (one patch) applied to the skin and worn for one half of a week. Then, remove that patch and apply and wear a new patch for the rest of the week. A new patch should be applied two times a week for three weeks. During the fourth week, you may or may not apply new patches. Your health care professional will tell you what you should do for this fourth week. After the fourth week, you will repeat the cycle.



  • For estradiol cypionate

  • For injection dosage form:
    • For treating ovary problems (female hypogonadism):
      • Adults—1.5 to 2 milligrams (mg) injected into a muscle once a month.


    • For treating symptoms of menopause:
      • Adults—1 to 5 milligrams (mg) injected into a muscle every 3 to 4 weeks.



  • For estradiol valerate

  • For injection dosage form:
    • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), symptoms of menopause, or ovary problems (female hypogonadism or failure or removal of both ovaries):
      • Adults—10 to 20 milligrams (mg) injected into a muscle every 4 weeks as needed.


    • For treating prostate cancer:
      • Adults—30 milligrams (mg) injected into a muscle every 1 or 2 weeks.



  • For estrone

  • For injection dosage form:
    • For controlling abnormal bleeding of the uterus:
      • Adults—2 to 5 milligrams (mg) a day, injected into a muscle for several days.


    • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
      • Adults—0.1 to 0.5 milligram (mg) injected into a muscle 2 or 3 times a week. Your doctor may want you to receive the medicine each week or only during certain weeks of the month.


    • For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
      • Adults—0.1 to 1 milligram (mg) a week. This is injected into a muscle as a single dose or divided into more than one dose. Your doctor may want you to receive the medicine each week or only during certain weeks of the month.


    • For treating prostate cancer:
      • Adults—2 to 4 milligrams (mg) injected into a muscle 2 or 3 times a week.



  • For estropipate

  • For oral dosage form (tablets):
    • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
      • Adults—0.75 to 6 milligrams (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
      • Adults—1.5 to 9 milligrams (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • To prevent loss of bone (osteoporosis):
      • Adults—0.75 milligram (mg) a day. Your doctor may want you to take the medicine each day for twenty-five days of a thirty-one–day cycle.



  • For ethinyl estradiol

  • For oral dosage form (tablets):
    • For treating breast cancer in women after menopause and in men:
      • Adults—1 milligram (mg) three times a day.


    • For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
      • Adults—0.05 milligram (mg) one to three times a day for 3 to 6 months. Your doctor may want you to take the medicine each day or only on certain days of the month.


    • For treating prostate cancer:
      • Adults—0.15 to 3 milligrams (mg) a day.


    • For treating symptoms of menopause:
      • Adults—0.02 to 0.05 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.



  • For ethinyl estradiol and norethindrone

  • For oral dosage form (tablets):
    • For treating symptoms of menopause:
      • Adults—1 tablet (5 mcg ethinyl estradiol and 1 mg of norethindrone) each day.


    • To prevent loss of bone (osteoporosis):
      • Adults—1 tablet (5 mcg ethinyl estradiol and 1 mg of norethindrone) each day.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Oesclim


It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects. These visits will usually be every year, but some doctors require them more often.


In some patients using estrogens, tenderness, swelling, or bleeding of the gums may occur. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your medical doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums.


Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast, ovaries, or uterus (womb). Therefore, it is very important that you regularly check your breasts for any unusual lumps or discharge. Report any problems to your doctor. You should also have a mammogram (x-ray pictures of the breasts) done if your doctor recommends it. Because breast cancer has occurred in men taking estrogens, regular breast self-exams and exams by your doctor for any unusual lumps or discharge should be done.


If your menstrual periods have stopped, they may start again. This effect will continue for as long as the medicine is taken. However, if taking the continuous treatment (0.625 mg conjugated estrogens and 2.5 mg medroxyprogesterone once a day), monthly bleeding usually stops within 10 months.


Also, vaginal bleeding between your regular menstrual periods may occur during the first 3 months of use. Do not stop taking your medicine. Check with your doctor if bleeding continues for an unusually long time, if your period has not started within 45 days of your last period, or if you think you are pregnant.


Tell the doctor in charge that you are using this medicine before having any laboratory test because some results may be affected.


Check with your child's doctor right away if your child starts to have the following symptoms: nipple or breast swelling or tenderness in females, or enlargement of the breasts in males. Your child may have been exposed to Evamist® transdermal spray.


Do not allow your pets to lick or touch the arm where Evamist® transdermal spray was applied. Small pets may be sensitive to this medicine. Call your pet's veterinarian if your pet starts to have the following symptoms: nipple or breast enlargement, swelling of the vulva, or any signs of illness.


Oesclim Side Effects


Women rarely have severe side effects from taking estrogens to replace estrogen. Discuss these possible effects with your doctor:


The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. This risk seems to increase as the dose and the length of use increase. When estrogens are used in low doses for less than 1 year, there is less risk. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer.


Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast. Breast cancer has been reported in men taking estrogens.


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


The following side effects may be caused by blood clots, which could lead to stroke, heart attack, or death. These side effects occur rarely, and, when they do occur, they occur in men treated for cancer using high doses of estrogens.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Breast pain (in females and males)

  • fast heartbeat

  • fever

  • hives

  • hoarseness

  • increased breast size (in females and males)

  • irritation of the skin

  • itching of the skin

  • joint pain, stiffness, or swelling

  • rash

  • redness of the skin

  • shortness of breath

  • swelling of the eyelids, face, lips, hands, or feet

  • swelling of the feet and lower legs

  • tightness in the chest

  • troubled breathing or swallowing

  • weight gain (rapid)

  • wheezing

Less common or rare
  • Changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding)

  • chest pain

  • chills

  • cough

  • heavy non-menstrual vaginal bleeding

  • lumps in, or discharge from, breast (in females and males)

  • pains in the stomach, side, or abdomen

  • yellow eyes or skin

Rare - for males being treated for breast or prostate cancer only
  • Headache (sudden or severe)

  • loss of coordination (sudden)

  • loss of vision or change of vision (sudden)

  • pains in the chest, groin, or leg, especially in the calf of leg

  • shortness of breath (sudden and unexplained)

  • slurring of speech (sudden)

  • weakness or numbness in the arm or leg

Incidence not known
  • Abdominal or stomach bloating

  • abdominal or stomach cramps

  • acid or sour stomach

  • anxiety

  • backache

  • belching

  • blindness

  • blistering, peeling, or loosening of the skin

  • blue-yellow color blindness

  • blurred vision

  • change in vaginal discharge

  • changes in skin color

  • changes in vision

  • chest discomfort

  • clay-colored stools

  • clear or bloody discharge from nipple

  • confusion

  • constipation

  • convulsions

  • dark urine

  • decrease in the amount of urine

  • decreased vision

  • depression

  • diarrhea

  • difficulty with breathing

  • difficulty with speaking

  • dimpling of the breast skin

  • dizziness

  • double vision

  • dry mouth

  • eye pain

  • fainting

  • fluid-filled skin blisters

  • full feeling in upper abdomen or stomach

  • full or bloated feeling or pressure in the stomach

  • headache

  • heartburn

  • inability to move the arms, legs, or facial muscles

  • inability to speak

  • incoherent speech

  • increased urination

  • indigestion

  • inverted nipple

  • irregular heartbeats

  • light-colored stools

  • lightheadedness

  • loss of appetite

  • loss of bladder control

  • lump under the arm

  • metallic taste

  • migraine headache

  • mood or mental changes

  • muscle cramps in the hands, arms, feet, legs, or face

  • muscle pain

  • muscle spasm or jerking of all extremities

  • muscle weakness

  • nausea

  • noisy breathing

  • numbness or tingling of the hands, feet, or face

  • pain in the ankles or knees

  • pain or discomfort in the arms, jaw, back or neck

  • pain or feeling of pressure in the pelvis

  • pain, tenderness, swelling of the foot or leg

  • painful or tender cysts in the breasts

  • painful, red lumps under the skin, mostly on the legs

  • pains in the chest, groin, or legs, especially calves of the legs

  • partial or complete loss of vision in the eye

  • pelvic pain

  • persistent crusting or scaling of nipple

  • pinpoint red or purple spots on the skin

  • prominent superficial veins over affected area

  • red, irritated eyes

  • redness or swelling of the breast

  • sensitivity to the sun

  • severe headaches of sudden onset

  • skin thinness

  • skin warmth

  • slow speech

  • sore on the skin of the breast that does not heal

  • sore throat

  • sores, ulcers, or white spots in the mouth or on the lips

  • stomach discomfort, upset, or pain

  • sudden loss of consciousness

  • sudden loss of coordination

  • sudden onset of shortness of breath for no apparent reason

  • sudden onset of slurred speech

  • sudden vision changes

  • swelling of the abdominal or stomach area

  • swelling of the fingers or hands

  • thirst

  • tremor

  • unpleasant breath odor

  • unusual tiredness or weakness

  • vomiting

  • vomiting of blood

  • weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Abnormal growth filled with fluid or semisolid material

  • accidental injury

  • bladder pain

  • bloated full feeling

  • bloody or cloudy urine

  • body aches or pain

  • coating or white patches on tongue

  • congestion

  • cough producing mucus

  • decrease in amount of urine

  • difficult, burning, or painful urination

  • discouragement

  • dryness of the throat

  • ear congestion or pain

  • excess air or gas in the stomach or intestines

  • fear

  • feeling of warmth

  • feeling sad or empty

  • frequent urge to urinate

  • general feeling of discomfort or illness

  • headache, severe and throbbing

  • increased clear or white vaginal discharge

  • irritability

  • itching of the vaginal, rectal or genital areas

  • lack of appetite

  • lack or loss of strength

  • loss of interest or pleasure

  • mild dizziness

  • neck pain

  • nervousness

  • pain

  • pain during sexual intercourse

  • painful or difficult urination

  • pain or tenderness around the eyes and cheekbones

  • passing gas

  • redness of the face, neck, arms, and occasionally, upper chest

  • runny nose

  • skin irritation or redness where skin patch was worn

  • shivering

  • sleeplessness

  • sneezing

  • sore mouth or tongue

  • stuffy nose

  • sudden sweating

  • tender, swollen glands in the neck

  • thick, white vaginal discharge with no odor or with a mild odor

  • tiredness

  • trouble concentrating

  • trouble sleeping

  • unable to sleep

  • voice changes

Less common
  • Blemishes on the skin

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

  • burning or stinging of the skin

  • diarrhea (mild)

  • difficulty with moving

  • dizziness (mild)

  • increased hair growth, especially on the face

  • lower abdominal or stomach pain or pressure

  • mood or mental changes

  • muscle stiffness

  • painful cold sores or blisters on the lips, nose, eyes, or genitals

  • pimples

  • pounding in the ears

  • problems in wearing contact lenses

  • slow heartbeat

  • tooth or gum pain

  • unusual decrease in sexual desire (in males)

  • unusual increase in sexual desire (in females)

  • white or brownish vaginal discharge

Incidence not known
  • Abnormal turning out of cervix

  • changes in appetite

  • dull ache or feeling of pressure or heaviness in the legs

  • flushed, dry skin

  • fruit-like breath odor

  • increased hunger

  • irritability

  • large amount of triglyceride in the blood

  • leg cramps

  • patchy brown or dark brown discoloration of the skin

  • poor insight and judgment

  • problems with memory or speech

  • trouble recognizing objects

  • trouble thinking and planning

  • trouble walking

  • twitching, uncontrolled movements of the tongue, lips, face, arms, or legs

  • unexpected or excess milk flow from the breasts

Also, many women who are taking estrogens with a progestin (another female hormone) will start having monthly vaginal bleeding, similar to menstrual periods, again. This effect will continue for as long as the medicine is taken. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (total hysterectomy).


This medicine may cause loss or thinning of the scalp hair in some people.


Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



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